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1

In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S1‘ Subsite and Its Implications to Structure-Based Drug Design1

Costanzo, Michael J., Almond, Harold R., Hecker, Leonard R., Schott, Mary R., Yabut, Stephen C., Zhang, Han-Cheng, Andrade-Gordon, Patricia, Corcoran, Thomas W., Giardino, Edward C., Kauffman, Jack A.

Journal:

Journal of Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 845 KB

english, 2005

2

Structure–Function Analysis of Urotensin II and Its Use in the Construction of a Ligand–Receptor Working Model

William A. Kinney, Harold R. Almond, Jr., Jenson Qi, Charles E. Smith, Rosemary J. Santulli, Lawrence de Garavilla, Patricia Andrade-Gordon, Daniel S. Cho, Anita M. Everson, Mark A. Feinstein, Perry A

Journal:

Angewandte Chemie

Année:

2002

Langue:

english

Fichier:

PDF, 151 KB

english, 2002

3

Structure–Function Analysis of Urotensin II and Its Use in the Construction of a Ligand–Receptor Working Model

William A. Kinney, Harold R. Almond, Jr., Jenson Qi, Charles E. Smith, Rosemary J. Santulli, Lawrence de Garavilla, Patricia Andrade-Gordon, Daniel S. Cho, Anita M. Everson, Mark A. Feinstein, Perry A

Journal:

Angewandte Chemie International Edition

Année:

2002

Langue:

english

Fichier:

PDF, 151 KB

english, 2002

4

Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3

Han-Cheng Zhang, Kimberly B. White, Hong Ye, David F. McComsey, Claudia K. Derian, Michael F. Addo, Patricia Andrade-Gordon, Annette J. Eckardt, Bruce R. Conway, Lori Westover, Jun Z. Xu, Richard Look

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 207 KB

english, 2003

5

Participation of protease-activated receptor-1 in thrombin-induced microglial activation

Zhiming Suo, Min Wu, Syed Ameenuddin, Heidi E. Anderson, Jamie E. Zoloty, Bruce A. Citron, Patricia Andrade-Gordon, Barry W. Festoff

Journal:

Journal of Neurochemistry

Année:

2002

Langue:

english

Fichier:

PDF, 482 KB

english, 2002

6

Potent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone

Costanzo, Michael J., Yabut, Stephen C., Almond,, Harold R., Andrade-Gordon, Patricia, Corcoran, Thomas W., de Garavilla, Lawrence, Kauffman, Jack A., Abraham, William M., Recacha, Rosario, Chattopadh

Journal:

Journal of Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 347 KB

english, 2003

7

In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S 1 ‘ Subsite and Its Implications to Structure-Based Drug Design.

Costanzo, Michael J., Almond, Harold R., Hecker, Leonard R., Schott, Mary R., Yabut, Stephen C., Zhang, Han-Cheng, Andrade-Gordon, Patricia, Corcoran, Thomas W., Giardino, Edward C., Kauffman, Jack A.

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 6 KB

english, 2007

8

The Heterogeneity of Human Chorionic Gonadotropin (hCG). III. The Occurrence and Biological and Immunological Activities of Nicked hCG*

COLE, LAURENCE A., KARDANA, ANDREW, ANDRADE-GORDON, PATRICIA, GAWINOWICZ, MARY-ANN, MORRIS, JOHN C., BERGERT, ELIZABETH R., O’CONNOR, JOHN, BIRKEN, STEVEN

Journal:

Année:

1991

Langue:

english

Fichier:

PDF, 1.37 MB

english, 1991

9

ChemInform Abstract: Macrocyclic Hexapeptide Analogues of the Thrombin Receptor (PAR-1) Activation Motif SFLLRN.

David F. McComsey, Leonard R. Hecker, Patricia Andrade-Gordon, Michael F. Addo, Bruce E. Maryanoff

Journal:

Année:

1999

Fichier:

PDF, 26 KB

1999

10

ChemInform Abstract: 1,2,4-Triazolo[3,4-a]pyridine as a Novel, Constrained Template for Fibrinogen Receptor (GPIIb/IIIa) Antagonists.

Edward C. Lawson, William J. Hoekstra, Michael F. Addo, Patricia Andrade-Gordon, Bruce P. Damiano, Jack A. Kauffman, John A. Mitchell, Bruce E. Maryanoff

Journal:

Année:

2002

Fichier:

PDF, 32 KB

2002

11

Bridged Bicyclic Vasopressin Receptor Antagonists with V2-Selective or Dual V1a/V2 Activity.

Alexey B. Dyatkin, William J. Hoekstra, Dennis J. Hlasta, Patricia Andrade-Gordon, Lawrence de Garavilla, Keith T. Demarest, Joseph W. Gunnet, William Hageman, Richard Look, Bruce E. Maryanoff

Journal:

Année:

2003

Fichier:

PDF, 204 KB

2003

12

Design and evaluation of potent peptide-mimetic PAR1 antagonists

Claudia K. Derian, Bruce E. Maryanoff, Patricia Andrade-Gordon, Han-Cheng Zhang

Journal:

Drug Development Research

Année:

2003

Langue:

english

Fichier:

PDF, 407 KB

english, 2003

13

Regulation of plasminogen activators and type-1 plasminogen activator inhibitor by cyclic AMP and phorbol ester in rat astrocytes

Pedro Tranque, Richard Robbins, Frederick Naftolin, Patricia Andrade-Gordon

Journal:

Année:

1992

Langue:

english

Fichier:

PDF, 1.05 MB

english, 1992

14

Cyclotheonamide derivatives: Synthesis and thrombin inhibition. Exploration of specific structure-function issues

Bruce E Maryanoff, Han-Cheng Zhang, Michael N Greco, Karen A Glover, Jack A Kauffman, Patricia Andrade-Gordon

Journal:

Bioorganic & Medicinal Chemistry

Année:

1995

Langue:

english

Fichier:

PDF, 1.22 MB

english, 1995

15

Aza-bicyclic amino acid sulfonamides as α4β1/α4β7 integrin antagonists

Alexey B Dyatkin, William J Hoekstra, William A Kinney, Maria Kontoyianni, Rosemary J Santulli, Edward S Kimball, M Carolyn Fisher, Stephen M Prouty, William M Abraham, Patricia Andrade-Gordon, Dennis

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 265 KB

english, 2004

16

Potent nonpeptide vasopressin receptor antagonists based on oxazino- and thiazinobenzodiazepine templates

Jay M. Matthews, William J. Hoekstra, Alexey B. Dyatkin, Leonard R. Hecker, Dennis J. Hlasta, Brenda L. Poulter, Patricia Andrade-Gordon, Lawrence de Garavilla, Keith T. Demarest, Eric Ericson, Joseph

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 334 KB

english, 2004

17

Corrigendum to “Bridged bicyclic vasopressin receptor antagonists with V2-selective or dual V1a/V2 activity”: [Bioorg. Med. Chem. Lett. 12 (2002) 3081]

Alexey B. Dyatkin, William J. Hoekstra, Dennis J. Hlasta, Patricia Andrade-Gordon, Lawrence de Garavilla, Keith T. Demarest, Joseph W. Gunnet, William Hageman, Richard Look, Bruce E. Maryanoff

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 207 KB

english, 2004

18

Thrombin receptor (PAR-1) antagonists. Solid-Phase synthesis of indole-Based peptide mimetics by anchoring to a secondary amide

Han-Cheng Zhang, David F McComsey, Kimberly B White, Michael F Addo, Patricia Andrade-Gordon, Claudia K Derian, Donna Oksenberg, Bruce E Maryanoff

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 155 KB

english, 2001

19

1,2,4-Triazolo[3,4-a]pyridine as a novel, constrained template for fibrinogen receptor (GPIIb/IIIa) antagonists

Edward C Lawson, William J Hoekstra, Michael F Addo, Patricia Andrade-Gordon, Bruce P Damiano, Jack A Kauffman, John A Mitchell, Bruce E Maryanoff

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 125 KB

english, 2001

20

Bridged bicyclic vasopressin receptor antagonists with V2-Selective or dual V1a/V2 activity

Alexey B Dyatkin, William J Hoekstra, Dennis J Hlasta, Patricia Andrade-Gordon, Lawrence de Garavilla, Keith T Demarest, Joseph W Gunnet, William Hageman, Richard Look, Bruce E Maryanoff

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 119 KB

english, 2002

21

Synthesis and biological evaluation of novel indoloazepine derivatives as non-peptide vasopressin V2 receptor antagonists

Jay M Matthews, Michael N Greco, Leonard R Hecker, William J Hoekstra, Patricia Andrade-Gordon, Lawrence de Garavilla, Keith T Demarest, Eric Ericson, Joseph W Gunnet, William Hageman, Richard Look, J

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 131 KB

english, 2003

22

High-affinity thrombin receptor (PAR-1) ligands: a new generation of indole-based peptide mimetic antagonists with a basic amine at the C-terminus

Han-Cheng Zhang, Kimberly B. White, David F. McComsey, Michael F. Addo, Patricia Andrade-Gordon, Claudia K. Derian, Donna Oksenberg, Bruce E. Maryanoff

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 207 KB

english, 2003

23

Novel thrombin inhibitors that are based on a macrocyclic tripeptide motif

Michael N. Greco, Eugene T. Powell, Leonard R. Hecker, Patricia Andrade-Gordon, Jack A. Kauffman, Joan M. Lewis, Venkatapathy Ganesh, Alexander Tulinsky, Bruce E. Maryanoff

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1996

Langue:

english

Fichier:

PDF, 280 KB

english, 1996

24

Thrombin receptor (PAR-1) antagonists. Heterocycle-based peptidomimetics of the SFLLR agonist motif

William J. Hoekstra, Becky L. Hulshizer, David F. McComsey, Patricia Andrade-Gordon, Jack A. Kauffman, Michael F. Addo, Donna Oksenberg, Robert M. Scarborough, Bruce E. Maryanoff

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1998

Langue:

english

Fichier:

PDF, 456 KB

english, 1998

25

Macrocyclic hexapeptide analogues of the thrombin receptor (PAR-1) activation motif SFLLRN

David F. McComsey, Leonard R. Hecker, Patricia Andrade-Gordon, Michael F. Addo, Bruce E. Maryanoff

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1999

Langue:

english

Fichier:

PDF, 306 KB

english, 1999

26

Heterocycle-peptide hybrid compounds. Aminotriazole-containing agonists of the thrombin receptor (PAR-1)

David F. McComsey, Michael J. Hawkins, Patricia Andrade-Gordon, Michael F. Addo, Donna Oksenberg, Bruce E. Maryanoff

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1999

Langue:

english

Fichier:

PDF, 349 KB

english, 1999

27

Thrombin receptor-activating peptides (TRAPs): Investigation of bioactive conformations via structure–activity, spectroscopic, and computational studies

Marco A. Ceruso, David F. McComsey, Gregory C. Leo, Patricia Andrade-Gordon, Michael F. Addo, Robert M. Scarborough, Donna Oksenberg, Bruce E. Maryanoff

Journal:

Bioorganic & Medicinal Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 730 KB

english, 1999

28

Protease-Activated Receptor-2 (PAR-2) Is Present in the Rat Hippocampus and Is Associated with Neurodegeneration

Virginia L. Smith-Swintosky, Catherine T. Cheo-Isaacs, Michael R. D'Andrea, Rosemary J. Santulli, Andrew L. Darrow, Patricia Andrade-Gordon

Journal:

Journal of Neurochemistry

Année:

1997

Langue:

english

Fichier:

PDF, 873 KB

english, 1997

29

Inhibition of Melanosome Transfer Results in Skin Lightening1

Seiberg, Miri, Paine, Christine, Sharlow, Elizabeth, Andrade-Gordon, Patricia, Costanzo, Michael, Eisinger, Magdalena, Shapiro, Stanley S.

Journal:

The Journal of Investigative Dermatology

Année:

2000

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2000

30

Regulatory network of inflammation downstream of proteinase-activated receptors

Ricardo Saban, Michael R D'Andrea, Patricia Andrade-Gordon, Claudia K Derian, Igor Dozmorov, Michael A Ihnat, Robert E Hurst, Cindy Simpson, Marcia R Saban

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 1.73 MB

english, 2007

31

Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation

Ricardo Saban, Michael R D'Andrea, Patricia Andrade-Gordon, Claudia K Derian, Igor Dozmorov, Michael A Ihnat, Robert E Hurst, Carole A Davis, Cindy Simpson, Marcia R Saban

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 3.45 MB

english, 2007

32

Contribution of bone marrow-derived cells to the pro-inflammatory effects of protease-activated receptor-2 in colitis

Eric Hyun, Patricia Andrade-Gordon, Martin Steinhoff, Paul L. Beck, Nathalie Vergnolle

Journal:

Inflammation Research

Année:

2010

Langue:

english

Fichier:

PDF, 506 KB

english, 2010

33

Solid-phase parallel synthesis applied to lead optimization: Discovery of potent analogues of the GPIIb/IIIa antagonist RWJ-50042

William J. Hoekstra, Bruce E. Maryanoff, Patricia Andrade-Gordon, Judith H. Cohen, Michael J. Costanzo, Bruce P. Damiano, Barbara J. Haertlein, Bruce D. Harris, Jack A. Kauffman, Patricia M. Keane, Da

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1996

Langue:

english

Fichier:

PDF, 343 KB

english, 1996

34

Adamantane and Nipecotic Acid Derivatives as Novel β-Turn Mimics

William J. Hoekstra, Jeffery B. Press, Mary Pat Bonner, Patricia Andrade-Gordon, Patricia M. Keane, Kathleen A. Durkin, Dennis C. Liotta, Kevin H. Mayo

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1994

Langue:

english

Fichier:

PDF, 334 KB

english, 1994

35

CHARACTERIZATION OF RWJ-351647, A NOVEL NONPEPTIDE VASOPRESSIN V2 RECEPTOR ANTAGONIST

Joseph W Gunnet, Jay M Matthews, Bruce E Maryanoff, Lawrence De Garavilla, Patricia Andrade-Gordon, Bruce Damiano, William Hageman, Richard Look, Paul Stahle, Anthony J Streeter, Pamela G Wines, Keith

Journal:

Clinical and Experimental Pharmacology and Physiology

Année:

2006

Langue:

english

Fichier:

PDF, 154 KB

english, 2006

36

Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation

Niessen, Frank, Schaffner, Florence, Furlan-Freguia, Christian, Pawlinski, Rafal, Bhattacharjee, Gourab, Chun, Jerold, Derian, Claudia K., Andrade-Gordon, Patricia, Rosen, Hugh, Ruf, Wolfram

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 512 KB

english, 2008

37

Multiple mechanisms of vascular smooth muscle relaxation by the activation of Proteinase-Activated Receptor 2 in mouse mesenteric arterioles

John J McGuire, Morley D Hollenberg, Patricia Andrade-Gordon, Chris R Triggle

Journal:

British Journal of Pharmacology

Année:

2002

Langue:

english

Fichier:

PDF, 340 KB

english, 2002

38

Proteinase-activated receptor-1 (PAR-1) activation contracts the isolated human renal artery in vitro

Michele Tognetto, Michael R D'Andrea, Marcello Trevisani, Remo Guerrini, Severo Salvadori, Lorella Spisani, Carlo Daniele, Patricia Andrade-Gordon, Pierangelo Geppetti, Selena Harrison

Journal:

British Journal of Pharmacology

Année:

2003

Langue:

english

Fichier:

PDF, 251 KB

english, 2003

39

Proteinase-activated receptor-1 is an anti-inflammatory signal for colitis mediated by a type 2 immune response

Nicolas Cenac, Laurie Cellars, Martin Steinhoff, Patricia Andrade-Gordon, Morley Donald Hollenberg, John Lawrence Wallace, Stefano Fiorucci, Nathalie Vergnolle

Journal:

Inflammatory Bowel Diseases

Année:

2005

Langue:

english

Fichier:

PDF, 214 KB

english, 2005

40

The discovery of stannin in rat dorsal root ganglia using an integrated proteohistological approach

Stanley M. Belkowski, Raymond W. Colburn, Dennis J. Stone, Christopher R. Van Besien, Deborah Polkovitch, Patricia Andrade-Gordon, Michael R. D'Andrea

Journal:

Clinical Proteomics

Année:

2004

Langue:

english

Fichier:

PDF, 323 KB

english, 2004

41

NOE-derived conformation of GRGDSP cell adhesion recognition site in the presence of SDS micelles and integrin receptor GPIIB/IIIA

Kevin H. Mayo, Francis Fan, Mary Pat Beavers, Annette Eckardt, Patricia Keane, William J. Hoekstra, Patricia Andrade-Gordon

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1996

Langue:

english

Fichier:

PDF, 793 KB

english, 1996

42

Mechanisms underlying the nociceptive and inflammatory responses induced by trypsin in the mouse paw

Ana Flávia Paszcuk, Nara L.M. Quintão, Elizabeth S. Fernandes, Luiz Juliano, Kevin Chapman, Patricia Andrade-Gordon, Maria Martha Campos, Nathalie Vergnolle, João B. Calixto

Journal:

European Journal of Pharmacology

Année:

2008

Langue:

english

Fichier:

PDF, 722 KB

english, 2008

43

Pharmacological characterization of RWJ-676070, a dual vasopressin V1A/V2 receptor antagonist

Joseph W. Gunnet, Pamela Wines, Min Xiang, Philip Rybczynski, Patricia Andrade-Gordon, Lawrence de Garavilla, Tom J. Parry, Wai-man Cheung, Lisa Minor, Keith T. Demarest, Bruce E. Maryanoff, Bruce P.

Journal:

European Journal of Pharmacology

Année:

2008

Langue:

english

Fichier:

PDF, 905 KB

english, 2008

44

Thrombin receptor: An endogenous inhibitor of inflammatory pain, activating opioid pathways

Laurence Martin, Céline Augé, Jérôme Boué, Michelle C. Buresi, Kevin Chapman, Samuel Asfaha, Patricia Andrade-Gordon, Martin Steinhoff, Nicolas Cenac, Gilles Dietrich, Nathalie Vergnolle

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 496 KB

english, 2009

45

Emerging paradigms in applied bioinformatics

Sergey E. Ilyin, Albert Pinhasov, Anil H. Vaidya, Frank A. Amato, Jack Kauffman, Hong Xin, Patricia Andrade-Gordon, Carlos R. Plata-Salamán, Douglas E. Brenneman

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 130 KB

english, 2003

46

Novel Thiazole-Based Heterocycles as Selective Inhibitors of Fibrinogen-Mediated Platelet Aggregation

Sanfilippo, Pauline J., Andrade-Gordon, Patricia, Urbanski, Maud J., Beers, Kimberly N., Eckardt, Annette, Falotico, Robert, Ginsberg, Mark H., Offord, Steve, Press, Jeffrey B.

Journal:

Journal of Medicinal Chemistry

Année:

1995

Langue:

english

Fichier:

PDF, 2.08 MB

english, 1995

47

Protease-Activated Receptor-2 (PAR-2): Structure-Function Study of Receptor Activation by Diverse Peptides Related to Tethered-Ligand Epitopes

Bruce E. Maryanoff, Rosemary J. Santulli, David F. McComsey, William J. Hoekstra, Kenway Hoey, Charles E. Smith, Michael Addo, Andrew L. Darrow, Patricia Andrade-Gordon

Journal:

Archives of Biochemistry and Biophysics

Année:

2001

Langue:

english

Fichier:

PDF, 110 KB

english, 2001

48

Role of angiotensin II in the processes leading to ovulation

Patricia Andrade-Gordon, Tony Zreik, Rosanna Apa, Frederick Naftolin

Journal:

Biochemical Pharmacology

Année:

1991

Langue:

english

Fichier:

PDF, 685 KB

english, 1991

49

RGD induces conformational transition in purified platelet integrin GPIIb/IIIa-SDS system yielding multiple binding states for fibrinogen γ-chain C-terminal peptide

Kevin H. Mayo, Francis Fan, Mary Pat Beavers, Annette Eckardt, Patricia Keane, William J. Hoekstra, Patricia Andrade-Gordon

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 486 KB

english, 1996

50

Serine Protease Inhibition Reduces Post-Ischemic Granulocyte Recruitment in Mouse Intestine

Thomas Gobbetti, Nicolas Cenac, Jean-Paul Motta, Corinne Rolland, Laurence Martin, Patricia Andrade-Gordon, Martin Steinhoff, Elisabetta Barocelli, Nathalie Vergnolle

Journal:

The American Journal of Pathology

Année:

2012

Langue:

english

Fichier:

PDF, 2.08 MB

english, 2012